|Posted on:||2 February 2018 / 08:44|
Synonym: S-4, GTx-007
CAS No.: 401900-40-1
Appearance: White crystalline powder
Molecular mass 441.357 g/mol
Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by
GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic
hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.
In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic
This suggests that it is able to competitively block binding of dihydrotestosterone to its receptor
targets in the prostate gland, but its partial agonist effects at androgen receptors prevent the side effects associated with the anti-androgenic drugs traditionally used for treatment of BPH.
Usage An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
S-4 is designed for treating conditions such as muscle wasting, osteoporosis and benign prostatic
hypertrophy, using the non-steroidal androgen antagonist bicalutamide as a lead compound.As an orally
active partial agonist for androgen receptors, S-4 is effective in not only maintaining lean body mass
but actually increasing it.
SARMS such as S4 can cause muscle growth in the same manner as steroids, however unlike testosterone
and other anabolic steroids, SARMS (as nonsteroidal agents) do not produce the growth effect on prostate
and other secondary ****** organs.
The typical dose for cutting is 50 mg for a cycle of 6 to 8 weeks. The cycle should include using the product daily for 5 days and then taking 2 days off for the duration. Tasking the dose every day for the duration of the cycle can result in changes to vision.
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