|Posted on:||31 January 2018 / 09:46|
Chemical Properties colourless oily liquid
Usage r-butyrolactone is one kind of important fine chemicalintermediate, simultaneously also is one
kind of performance fine highboiling point solvent, ideal antioxidant, plasticizer,extracting agent, absorbent, dispersing agent, solid stain, Coagulation Reagent.
General Description Clear colorless oily liquid with a pleasant odor.
Air & Water Reactions Hygroscopic. Soluble in water.
Reactivity Profile gamma-Butyrolactone can react with oxidizing materials, inorganic acids and bases, alcohols and amines. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. gamma-Butyrolactone is volatile with steam. . The combination of the lactone, butanol, 2,4-dichlorophenol, and sodium hydroxide
in the attempted synthesis of 2,4-dichlorophenoxybutyric acid caused a thermal runaway reaction that eventually exploded, [CISHC Chem. Safety Summ., 1977, 48, 3].
Fire Hazard gamma-Butyrolactone is combustible.
1). Used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone, polyvinyl pyrrolidone, and
α -Acetyl-γ -butyrolactone;
2). used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the
intermediate of vitamin and rolicyprine;
3). As antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent;
4). Used in battery, capacitor and development of color film.
Gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless liquid with a weak
characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as well
as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some
wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as a recreational intoxicant with effects similar to alcohol.
GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution
into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions
it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic (fat soluble) than GHB,
and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences,
GBL tends to be more potent and faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.
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