|Posted on:||3 February 2018 / 07:34|
CAS No: 137-58-6
Appearance: White crystalline powder
Melting point: 66-69º C
Water solubility: Practically insoluble
Storage: Store in a well-closed container away from moisture and strong light
Lidocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or used as a local anesthetic for minor surgery.
It is on the World Health Organization’s List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.
Indications and Usage
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; Lidocaine, though, has the advantage of a rapid onset of action.
Epinephrine vasocon stricts arteries, reducing bleeding and also delays the resorption of lidocaine,
almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e. G. For endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing
less painful. Lidocaine drops can be used on the eyes for short ophthalmic procedures.
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