|Posted on:||31 January 2018 / 08:13|
Product Categories: Weight Loss;SR141716
Mol File: 168273-06-1.mol
Usage: Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane
Rimonabant Brief introduction:
Rimonabant has also been shown to be a μ-opioid receptor antagonist (possibly the contributing factor in
its reported dysphoric qualities).Its main effect is reduction in appetite.
In a 2006 (2 year) study reported in JAMA, “Compared with the placebo group, the 20 mg of rimonabant
group produced greater mean (SEM) reductions in weight (-6.3 [0.2] kg vs -1.6 [0.2] kg; P<.001), waist circumference (-6.1 [0.2] cm vs -2.5 [0.3] cm; P<.001), and level of triglycerides (percentage change,
-5.3 [1.2] vs 7.9 [2.0]; P<.001) and a greater increase in level of high-density lipoprotein cholesterol (percentage change, 12.6 [0.5] vs 5.4 [0.7]; P<.001)."
Rimonabant may also be found to be effective in assisting some smokers to quit smoking. Sanofi is
currently conducting studies to determine the possible value of rimonabant in smoking-cessation therapy.
The Studies with Rimonabant and Tobacco Use (STRATUS) program involves more than 6,000 subjects. STRATUS
is designed to explore two smoking-related therapies: first, to use rimonabant directly to aid in smoking cessation; second, to help prevent weight gain in former smokers. Initial results apparently suggest rimonabant is effective for both uses. However, the FDA has explicitly stated to Sanofi that, without additional studies, rimonabant cannot be approved in the United States for smoking cessation therapy. According to a Cochrane Collaboration review in 2007, rimonabant "may increase the odds of quitting approximately 11/2-fold".
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